ASHWAGANDHA

STRESS SUPPORT AND MENTAL CLARITY*

OVERVIEW

Ashwagandha, a key component of Ayurvedic tradition, has been widely studied for its ability to support stress management, immune health, and overall wellness. This adaptogenic herb helps the body maintain balance by modulating its stress response, supporting hormonal equilibrium, promoting restful sleep, and aiding in tissue recovery. By incorporating Ashwagandha into your routine, you can help support your body’s natural mechanisms for achieving resilience and vitality.

HORMONE SUPPORT

Adaptogenic Support for Cortisol Regulation

Ashwagandha is recognized for its adaptogenic properties, meaning it helps the body adapt to stressors and normalize physiological functions. By modulating the release of stress hormones like cortisol, Ashwagandha may support the restoration of hormonal balance. Research suggests it may help maintain healthy cortisol levels, contributing to overall hormonal equilibrium.1

HPA Axis Modulation

Ashwagandha supports the hypothalamic-pituitary-adrenal (HPA) axis, a network involved in regulating stress responses and hormone production. Chronic stress can dysregulate this system, leading to imbalances. Studies indicate Ashwagandha helps maintain balance within the HPA axis, enhancing its feedback mechanisms and promoting normal hormone secretion.2

Thyroid Function Support

Emerging research shows that Ashwagandha may support optimal thyroid function by influencing thyroid-stimulating hormone (TSH) levels, contributing to healthy metabolic activity and hormone regulation.3

STRESS AND SLEEP SUPPORT

Promotes Relaxation and Restful Sleep

Ashwagandha supports gamma-aminobutyric acid (GABA) activity, an inhibitory neurotransmitter associated with calming neuronal excitability. By enhancing GABAergic signaling, Ashwagandha may promote relaxation and support better sleep quality.4

Neurotransmitter Balance

Ashwagandha has been studied for its effects on key neurotransmitters such as serotonin, dopamine, and norepinephrine, which play a role in mood regulation and stress response. Supporting the balance of these neurotransmitters contributes to emotional well-being and stress management.

Cellular Stress Resilience

Ashwagandha activates pathways like the heat shock protein (HSP) system, which protects cells from stress-induced damage. This mechanism helps individuals adapt to stress more effectively, reducing its negative impact on sleep and overall health.1

TISSUE RECOVERY AND IMMUNE SUPPORT

Supports Tissue Recovery

Ashwagandha contains bioactive compounds, including alkaloids and flavonoids, that support an optimal environment for normal tissue repair. This makes it a valuable addition for individuals engaging in physical activity and recovering from exercise-related strain.

Enhances Immune Function

Ashwagandha's immunomodulatory properties support key immune cells such as natural killer (NK) cells, macrophages, and lymphocytes. This effect may help promote overall immune system health.5-6

REFERENCES

1. Salve J, Pate S, Debnath K, Langade D. ACureus. 2019 Dec 25;11(12):e6466. doi: 10.7759/cureus.6466. PMID: 32021735; PMCID: PMC6979308.

2. Lopresti AL, Smith SJ, Malvi H, Kodgule R. Medicine (Baltimore). 2019 Sep;98(37):e17186. doi: 10.1097/MD.0000000000017186. PMID: 31517876; PMCID: PMC6750292.

3.Sharma AK, Basu I, Singh S. J Altern Complement Med. 2018 Mar;24(3):243-248. doi: 10.1089/acm.2017.0183. Epub 2017 Aug 22. PMID: 28829155.

4. Candelario M, Cuellar E, Reyes-Ruiz JM, Darabedian N, Feimeng Z, Miledi R, Russo-Neustadt A, Limon A. J Ethnopharmacol. 2015 Aug 2;171:264-72. doi: 10.1016/j.jep.2015.05.058. Epub 2015 Jun 9. PMID: 26068424.

5. Barua A, Bradaric MJ, Bitterman P, Abramowicz JS, Sharma S, Basu S, Lopez H, Bahr JM. Am J Reprod Immunol. 2013 Dec;70(6):538-50. doi: 10.1111/aji.12172. Epub 2013 Nov 5. PMID: 24188693.

6. Singh N, Bhalla M, de Jager P, Gilca M. Afr J Tradit Complement Altern Med. 2011;8(5 Suppl):208-13. doi: 10.4314/ajtcam.v8i5S.9. Epub 2011 Jul 3. PMID: 22754076; PMCID: PMC3252722.