CONTROL

OVERVIEW

Control is a cutting-edge supplement meticulously formulated to optimize health and metabolic function. Within its innovative blend of ingredients, Control harnesses the power of scientific research to unlock the potential of the body’s intricate biochemistry. The synergistic blend combines MitoBurn®, GlucoV antage®, Factor21®Bitter Melon Extract, InnoSlim®, Actiponin®, and CaloriBurn GP®, Control to revolutionize your well-being. Promoting Brown Adipose Tissue (BAT) conversion, thermogenesis activation, insulin sensitivity and glucose utilization and AMPK activation, Control is designed to optimize energy expenditure, well-being, and vitality.

INGREDIENTS

MitoBurn®

MitoBurn® (B-aminoisobuytric acid, L-BAIBA) known for activation of BA T via the same genetic influence as bitter melon extract and also for energy expenditure. It accomplishes this by aiding the peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-la), a transcriptional coactivator that plays a key role in regulating energy metabolism and mitochondrial biogenesis.1 This activation occurs by way of AMPK, one of the various signaling pathways that regulate the shift from white to brown adipose tissue.

Factor21®

Factor21® Bitter Melon Extract (Momordica charantia), is derived from bitter melon's effect on a hormone called Fibroblast Growth Factor 21 (FGF21). Specifically, bitter melon extract has been shown to enable the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARa), which in turn leads to the activation of FGF21. Benefits of this include supporting insulin sensitivity and glucose tolerance. It has also been shown to support insulin sensitivity by increasing glucose uptake and utilization in cells. This is accomplished by aiding AMPK as well as the translocation of glucose transporter 4 (GLUT4) to the cell membrane. GLUT4 is responsible for transporting glucose from the blood into cells. and increasing its translocation to the cell membrane.2,3

GlucoVantage®

GlucoVantage® (Dihydroberberine), a chemical analog of berberine. has also been shown to support healthy insulin sensitivity levels via AMPK and supporting glucose uptake and utilization in muscle cells. Dihydroberberine is a new version of traditional berberine that is up to Sx more bioavailable/absorbable and 2x longer lasting (8 hours vs. 4 hours).5 And while GlucoV antage represents an enhanced version of berberine, berberine HCl in itself holds incredible potential in supporting metabolism via its effect on the microbiota.6

InnoSlim®

InnoSlim®, a combination of Astragalus membranaceus and Panax notoginseng, has also been shown to support AMPK as well as a key hormone called adiponectin, which is linked to higher levels of insulin sensitivity and supporting healthy glucose metabolism.7 Additionally, it was found in one study that InnoSlim® regulates glucose absorption in the intestine by assisting beneficial transporters, such as GLUT4, which optimize glucose uptake in the muscle and fat cells.8,9

Actiponin®

Actiponin®, also supports AMPK for optimal glucose and lipid metabolism, as well as energy production throughout the body. When active and functioning in the manner it is supposed to, this powerful enzyme balances the activity of catabolic ATP-generating pathways like fatty acid 13-oxidation, glycolysis. and glucose uptake (processes that normally occur during intensive exercise or prolonged starvation) with other anabolic A TP-consuming pathways like fatty acid and cholesterol synthesis.10

CaloriBurn GP®
CaloriBurn GP®, a grains of paradise extract containing 6-paradol, has been shown to support BA T and thermogenesis, leading to optimal energy expenditure and metabolic health.11 Brown adipose tissue (BA T) is a specialized type of fat tissue that is involved in thermogenesis leading to healthy levels of energy expenditure and glucose and lipid metabolism.

REFERENCES

1. Tanianskii DA, Jarzebska N, Birkenfeld AL, O'Sullivan JF, Rodionov RN. Nutrients. 2019 Fe 28;11(3):524.

2. Tan MJ, Y e JM, Turner N, Hohnen-Behrens C, Ke CQ, et al. (2008) Chem Biol 15: 263–273.

3. Joseph B, Jini D. Asian Pac J Trop Dis. 2013 Apr;3(2):93–102.

4. Turner N, Li JY , Gosby A, To SW, Cheng Z, Miyoshi H, Taketo MM, Cooney GJ, Kraegen EW, James DE, Hu LH, Li J, Y e JM. Diabetes. 2008 May;57(5):1414-8.

5. Feng R, Shou JW, Zhao ZX, He CY , Ma C, Huang M, Fu J, Tan XS, Li XY , Wen BY , Chen X, Y ang XY , Ren G, Lin Y , Chen Y , Y ou XF, Wang Y , Jiang JD. Sci Rep. 2015 Jul 15;5:12155. doi: 10.1038/srep12155. PMID: 26174047; PMCID: PMC4502414.

6. Och A, Och M, Nowak R, Podgórska D, Podgórski R. Berberine, a Molecules. 2022 Feb 17;27(4):1351. doi: 10.3390/molecules27041351. PMID: 35209140; PMCID: PMC8874997.

7. S.C. Huang, etc. J of Biochemistry and Biotechnology, August 2021.

8. T.C. Chang, et al. Journal of Agricultural Food Chemistry. 2007, 55, 1993-1998.

9. Y .C. Huang, et al. Journal of Agricultural Food Chemistry. 2010, 58, 6039–6047. DOI:10.1021/jf9034755.

10. Park SH, Huh TL, Kim SY , Oh MR, Tirupathi Pichiah PB, Chae SW, Cha YS. Obesity (Silver Spring). 2014 Jan;22(1):63-71.

11. Sugita J, Y oneshiro T, Sugishima Y , Ikemoto T, Uchiwa H, Suzuki I, Saito M. J Nutr Sci Vitaminol (Tokyo). 2014;60(1):22-7.